Update on quantitative ultrasound (QUS) Assessment of Bone

Speaker: Prof. Pascal Laugier (Université Pierre et Marie Curie)

Time and Date: 9:00- , Oct. 20, 2014

Place: Room 521, Physicss Building, Handan Campus

 

 

Abstract

The last two decades have witnessed changes in our ability to assess multiscale mechanical properties of the human skeleton. Ultrasound have played a critical role in this development. Work conducted in quantitative ultrasound (QUS), taking benefit of the scalability of ultrasound, suggests the existence of significant advantages in bone quality information, as well as the presence of numerous challenges. With the development of engineering and methodological solutions to these challenges, QUS methods have provided gains in bone mechanical status assessment, spanning the scales of bone organization ranging from elementary bone structural units to the organ level. These include scanning acoustic microscopy and ultrasonic resonant spectroscopy. These techniques can help in characterizing the anisotropic stiffness in vitro and are prone to provide answers to some questions that remain open regarding the determinants of cortical bone elastic properties. Relationships of quantitative ultrasound variables with structural and elastic properties will be illustrated through examples.

On the other side, a specific appealing aspect of in vivo QUS techniques is their potential to account for important bone quality factors like material properties or structure, and particularly those of cortical bone, which cannot easily be captured with X-ray densitometry techniques. Although still at an early stage of development, recent QUS approaches using guided waves propagating axially or circumferentially in the cortical shell seem to be promising to reveal bone properties beyond bone mineral quantity. We will show how new data acquisition and signal processing procedures are prone to reveal bone properties beyond bone mineral quantity.

As extensive as they are, these gains still constitute a prelude to what is to come, given the incessant developments of better instrumentation and signal processing techniques.

 

 

Biography

Pascal Laugier，巴黎第六大学，教授，欧洲科学院院士。

1987年于巴黎第七大学获物理声学专业博士学位，现任巴黎第六大学生物医学成像实验室主任，法国国家科学研究中心(CNRS)研究员。

Laugier博士曾获1993年度法国CNRS的铜质勋章，1998年度法国物理学会Yves Rocard奖，2001年度欧洲重大创新奖，2009年度法国声学学会勋章。他于2003年当选为欧洲科学院院士，美国医学生物工程学会(AIMBE)Fellow，美国声学学会(ASA)Fellow，美国超声医学学会荣誉Fellow，现任《IEEE Trans on UFFC》副主编，以及包括《Ultrasound in Medicine and Biology》与《Ultrasonic Imaging》在内的多个期刊编委。已发表论文近200篇，有12项发明专利，著有《Bone Quantitative Ultrasound》。其研究领域主要为超声及其成像学在生物医学工程中的应用。